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Thesmooth muscle of the lower part of the esophagus is inner-vated by visceral motor neurons ofthe vagus (from the dorsalmotor nucleus). Disorders most often includedin studies of internalizing problems include those that encompass characteristicsof “anxiety, fear, and misery” associated with “major depressive disorder (MDD),generalizedanxietydisorder(GAD),separationanxietydisorder(SAD),panicdis-order (PD), and phobias” (Mikolajewski, Allan, Hart, Lonigan, & Taylor, 2012,p

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Experimental therapeutics and preclinical studies have demonstrated thatMDM2 antagonists can be used alone or in combination regimens with cytotoxicdrugs or other molecule-targeted drugs. In addition to increasing oxidative stress levels, it is associated with decreasedlevels of vitamin C and glutathione, and important antioxidant.

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